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JAMA 2001, 285: 2486-97 D.Sibarov, R.Kovalenko, V.Malinin, V.Khavinson, Epitalon influences pineal secretion in stress-exposed rats in the daytime

The histidine residue serves as the primary copper-binding site through its imidazole ring, creating a stable square-planar copper(II) complex with the amino terminal and adjacent peptide nitrogen atoms

The compound acts on the enzyme directly and does not engage central nervous system receptors